In the earliest known record of his musical career, David Marley performed as part of a singing group called The Seven Do Bees, made up of him and his classmates, and wherein he was given the stage name "Freddie Dic". The moniker never stuck, however, and instead David went on to become known as "Ziggy", a nickname given to him by his father Bob Marley, meaning ‘little spliff’. But Ziggy states the following to Melody Maker Magazine in 1988: "Me name David but me big Bowie Fan. So at the time of the 'Ziggy Stardust' album, me call meself Ziggy and now everyone do."
Ziggy Marley's debut solo album, Dragonfly was released on 15 April 2003. The album featured the single "True To Myself." The track "Rainbow in the Sky" features both Flea and John Frusciante of the Red Hot Chili Peppers, while "Melancholy Mood" features only Flea.
On 2 July 2006, his second solo album, Love Is My Religion, was released on his independent record company Tuff Gong Worldwide. The album carried on the reggae-style pop sound and the lyrical themes established in Dragonfly. The album won a Grammy Award for Best Reggae Album, making it Ziggy's 4th Grammy win.
On 15 April 2014, Ziggy Marley came out with his fifth solo studio album, entitled Fly Rasta, with "Background Vocals from Cedella Marley, Sharon Marley, Rica Newell, Tracy Hazzard, Ian "Beezy" Coleman, Vincent Brantley, Sean Dancy, and Tim Fowlles". Songs like " I Don't Wanna Live on Mars" and "Sunshine", show the emotion that Ziggy tried to portray in this new album. Fly Rasta won the Grammy for Best Reggae Album at the 57th Grammy Awards.
In 2016, Ziggy Marley has released his sixth solo studio album, Ziggy Marley, through Tuff Gong Worldwide. Recorded in Los Angeles and produced by Ziggy, the new self-titled album marks his first release in 2 years.